Ill be experiencing this shortly.
I have the original naga and when I was looking for updates a few months ago I saw synapse.
Gave that a whirl and it kill my macros and settings I already had, then hassles with logging in, etc.
So I run the old app and says no Naga mouse detected.
I had to uninstall synapse and the original drivers, reboot, install the old ones and all was fine again.
This week bestbuy has the new 2012 Naga for $60 and their Gamer magazine has a $20 off coupon.
So for 40, i couldn't pass it up. I got it yesterday and going to deal with Synapse tonight.
Side note I opted for the 2 year protection for $12 because once my current naga dies Id like to pull a switcharoo on them and return the old one.
I used to work there so I know some hustles. Hell, I had to walk 2 cashiers yesterday on how to ring up the coupons and protection plan properly.