I've got an issue since moving my AE-5 to the very bottom PCIE slot on my Asus Maximus X-Hero due to a GPU change. The Blaster X Engine doesn't appear to working. When I toggle the Blaster X switch on and off I hear no audible difference. Also the various presets aren't loading their Blaster X settings when I cycle them. I've tried reinstalling the driver and software and initially it seemed like it was normal but it has returned to this. I'm wondering if I should try removing all left over file/folders as part of another reinstall... Everything was totally normal on the PCIE slot above it.
Maybe disabling the onboard audio in bios will help. I haven't had a problem with motherboard and discrete audio enabled a the same time, but I've heard others have. And you could try setting the pciex4_3 slot you have that card plugged into to x1, since that is all it needs.