Originally Posted by PsyM4n
It will lead to issues under extreme scenarios.
Remember, threadripper is essentially epyc, if/when a 32-core part comes out, the power requirements under extreme overclocks will be immerse. Putting the power plugs so far is asking for trouble.
It won't cause any issues even if your CPU consumes 2x the rated TDP and if the VRM had efficiency of 80%. 450W / 12 = 37.5A.
X399 boards cannot support 4MCM EPYCs as they're only wired for four memory channels (two dies / 2MCM).