In the Throttlestop overclocking thread at TPU Unclewebb, the developer of TS goes through the X58settings on around page 4. 4.15Ghz seems typical for Prime 95, and 4.3Ghz for softer gaming benchmarks.
For RAM speed on locked boards you can try chasing lower latency. PC Wizard lets you read all the latency speeds at various clock speeds the RAM is programmed for.
On my LGA775 Optiplex 380 GSkill Ripjaws CAS7 1333 DDR3 runs at CAS6 on the 1066 bus speed. I've never seen these timings for lower than rated clock speeds published.
There may be some DDDR3 1600 or 1866 modules that will run faster at 1333 speed.
Most locked BIOS boards don't have any VRM cooling. You can glue some heatsinks on yourself for an improvement there. I would suggest separate heatsinks for each MOSFET. Expansion must be accounted for if you try to add 1 big heatsink, and the MOSFETs aren't always level with each other. Either Arctic 2 part thermal cement, or many people just use Superglue. Alphacool, and Enzotech both sell MOSFET heatsink kits. I've had this mod make more Voltage available to the CPU.
There is a TDP Wattage control, and a separate TDC current (Amperage)control. If you look at the equation Amps X Volts=Watts you will see that lower Amps will require higher Voltage for the same Watts output. Of course raisng Voltage by an indirect method like this is risky business since you don't know what Voltage you will actually end up with. What the Auto settings will actually allow is unknown so far.