Here's a little thought I've had for a good while: Why are there no properly ergonomic gaming-capable mice in the market? I mean, all the gaming mice marketed as ergonomic don't really put your hand into its most natural position. They force you to twist your wrist to zero angle in relation to your desk (which is not good), and as far as I know, none of them properly "fill" your entire palm and support the natural position of one's knuckle joints at the same time. The only mice I'm aware of that would be decent ergonomics-wise seem to be packing bad sensors, and their ergonomic shape is usually "overdone".
Are manufacturers afraid to try genuinely new shapes? Or do they just think classic shapes like IME 3.0 and MX518 really are the best you can get? While I like ergonomic mice, I feel like I've never encountered one that didn't force me to change from my hand's relaxed position.