Originally Posted by SpirosKGR
I didn't have any problems with the same motherboard at my cousin's pc. Same specs except the graphics card.
Its the best z390 ITX motherboard out there with strong VRM I don't think this is the problem but maybe ask amazon for an rma ?
I have already disable any usb power saving mode at device manager
I thought it could be result of power saving features kicking-in, not the issue with the mobo, but it could be the mobo too.
but if you have the same issue under 2 operating systems and multiple mice, I would change the mobo.