Not to the degree of asymmetrical ergonomic mice, and I wouldn't expect it to be so. But I'd still expect it to be designed for the maximal comfort of the average human hand, would that not be correct? Like, for example, the ZA shape; while I have my own issues with it (and I would not be comfortable using it other than desktop work), I'd say that overall, it respects good basic design principles in its curves and shape.
Since white pads tend to raise LOD and the Model O-'s sensor has LOD set too low which hampers performance, I just tried placing a white paper towel over my black hard pad and using the Model O- on top of it. The mouse acts a bit more like a standard 3360/3366 when doing so. A white cloth pad is probably what people should be using with these things.
Using this mouse on a black pad, the sensor just doesn't stack up against the Logitech 3366 at all IMO. That small gain in LOD on a white surface seems to help a lot, though. Setting LOD to +1mm in software doesn't help and just makes tracking worse, so a white pad seems to be about the only viable solution with these things.