tbh i'm spitballing a little here but yeah there will be some latency; just compare using native (on the chipset) than third party chips that expand the port on a mobo. and as w/those, it depends on the chips (manufacturer) and drivers. i guess you could negate some of that by sacrificing X8 lanes plugging it into the second x16 slot but why?
however going through a google search; seems to be more of issues w/audio, didn't see anything about KB/M. i suspect YMMV since its all about the drivers.
Remember the golden rule of statistics: A personal sample size of one is a sufficient basis upon which to draw universal conclusions.
Upload the computer to Dropbox and provide a link to it so others may download it to examine and give advice for repairs.
Asus P8Z77-V Pro
PNY 1311 240Gb
EVGA SuperNova 750 G2
Stryker M [hammered and drilled]
Ducky Zero [blues]
Klipsch ProMedia 2.1
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