Old school watercooler here.
I can attest to the "single pump is all ya need" point. It really is. A single D5 will do the job, no issue. All I run are these
and...HOLY JEEZ THEY ARE $90 NOW??!!! Why, back in my day it was known as a DangerDen D5 and it cost about $50. Dang.
Your issue is going to be proper radiator sizing. You gotta get them watts outta there! So do your research on the heat load generated and get enough of and the right size rads. Take the load rating of the rads published and subtract 25. That should help account for any real world conditions they don't have in the testing lab. For example, my 7900x delidded is a nightmare even on a 360mm rad. At load there is just straight heat blowing out of it and after an hour or so the rad starts to get warm to the touch. In my case, I probably need a bigger and/or more efficient rad.
Next is a proper case and fan/rad mounting and orientation. If all you're doing is dumping heat into the case, then you're gonna have a bad time.
How you plumb is preference. Hard or soft tubing, barbs and clamps or compression fittings. Up to you.
Actual blocks, just ask here. We all have experience with one block or another.