That almost sounds like a "Monsta" Rad.....that is extremely thick and I really do hope your planning a large case for it......mounting a huge (thick) rad can be challenging to have the lower Fan (you said push / pull clear the VRM's and other fittings on the top of the Board.
If your planning on running GPU / GPU's on same Loop consider multiple Rads (at least 2)...did I say to make sure you have a case large enough to comfortably fit not only rads...but the fittings.....
Personally the biggest reason I go with a Custom Loop is to cool my GPU's as they get extremely warm on air and loud!!!!
Building a custom loop in a Mid Size tower isnt impossible, but is challenging...particularly for your first WC'ing build......
Nothing wrong with a combo rez / pump....Ive been using an XSPC Photon combo with a D5 Vario pump for years....works great but again....you need the space to mount it.....
My Custom Loop isnt pretty (no hard lines), but very effective cooling and relatively easy to put together and maintain as I have a large case (Corsair 900D), I also run a think 480 rad up (65mm I think RX 480) top and a regular size 360 and 240 mm Rads down below.....
Im also running 15 Fans (at low speed 600RPM) all wired into a Lamptron 200W ( 4ch * 50W) Fan Controller....so the machine is fairly quiet....
For CPU Block and both GPU Blocks I go with EK all the way...always easy to install the GPU Blocks...shipping from Slovakia to Canada is painless and fast....
Link to my build:
https://rog.asus.com/forum/showthrea...00K-1080Ti-SLi
Ive included a pic so you get an idea of what a "non pretty / polished" WC loop looks like (CPU and 2 x 1080Ti's) ......I also have this tower sitting on a platform with wheels...so can be easily moved around if need be.....
The Mobo is an E-ATX Asus Maximus XI Extreme....
Good luck with the build.....and welcome to the Wet Head club!!!!!
9900K 5Ghz w EK Velocity / XSPC Photon Rez - Vario Pump Combo
MXIE w 32GB Platinum 3200
GTX 1080Ti SLi w FC EK Blocks / AX 1200i
Samsung 512G M.2 NVMe / Samsung 512G 860 Pro / Samsung 256G 860 Pro / WD 4 TB Red
Corsair 900D / 480*360*240 Rads - Dell Alienware 3440*1440p 120Hz
Timespy: 18.613K
https://www.3dmark.com/spy/5538409
Firestrike Ex: 23.772K
https://www.3dmark.com/fs/17562471