tsk, tsk, tsk wrong attitude
If your consumption is say 100 Gallon to the Mile, you're not going to win many races... because you're not going very far.
And if it is endurance, where fuel stops are allowed, you'ld be spending too much time in the pits getting fueled up
And even the quarter mile drag race is no longer on the table, since you would need at least 25 gallons just to finish the quarter mile... and 25 Gallons of fuel is HEAVY, which you would have to compensate with more HP, which then ups fuel consumption, needing more as 25 gallon. Also, you may have to cut your tyres differently to get all these HP to the tarmac, which might add weight... etc etc etc
On the bleeding edge... it all becomes very much rocket-science, doesn't it ?