PCI-E 1.1 x8? I would imagine it would be fine for the most part. I'd *guess* (since we don't really have any hardcore numbers for that yet) that at most you'd see a 5-10 FPS drop.
PCI-E 2.0 x8? Don't think so. PCI-E x8 2.0 is the same as PCI-E 1.1 x16, and thus higher bandwidth. Currently only dual GPU cards can completely fill an x16 slot.
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