Your FSB essentially IS your OC. If you're changing the front bus speed, you're changing how hard your board has to work, that is why it is harder to get a 500x8 OC than it is to get a 400x10. What you may want to try is increasing your NB voltage, it gives a little bit more "umph" to your OC and allows it to get a little higher. Don't make the value more than like 1.35V if it's passively cooled. I would suggest leaving your multiplier as high as it will go, as well.
EDIT: I'm using a DFI DK P35 with an E6750 and it's at 425, no issues. Could also be luck of the draw.
EDIT: I'm using a DFI DK P35 with an E6750 and it's at 425, no issues. Could also be luck of the draw.