This isn't particularly small or pretty, but it's fast and quiet and that's what I care about.
Thermaltake V21 - 200mm Noctua intake, 140mm Noctua exhaust
7700k @ 4.8Ghz (1.31v) Noctua DH-15s + 2x 140mm fans
1080 Ti @ 1885Mhz - Arctic Accelero Xtreme III + Noctua NF A-12 fans (1350rpm)
16GB @ 3733Mhz
Seasonic 600W Titanium PSU (fanless)
This system is nearly inaudible when idle and is able to run with the fans at 50-60% in most situations but the fans will go to 100% if the CPU hits 75C
The Arctic cooler is great, but I found that after less than a year, the fans produced unacceptably audible bearing noise. I pulled the shroud off and used a pair of the new Noctua Sterrox fans - they are super quiet and push a lot of air. Under load, the card never goes above the low 60s