i would personally suggest using super glue. take some super glue and lick it around the area that you are going to make a hole on in a circle. put dual layes. on both sides. afterward using a drill bit at low rpm drill a hole of and then u can start to cut at low to medium revs. works everytime
One more advice about drilling holes on acrylic, if u are using a drill make sure u dont push the drill. let the bit cut its hole, applying too much pressure on the drill may cause a crack on the other end on the plastic.
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