I just got a first gen g15 as well. I'm in the same situation as yourself and have absolutely no use of the 50+ macro keys.
It's definitely more useful in an mmo with more skills than you can put on a standard keyboard. But entirely useless for most fps games.
Some ideas that come to mind for macros might be chaining together use of certain items in warcraft 3/dota/hon. I've personally never played LoL, but maybe it's something to keep in mind since the game is based off of dota anyways.
When I first started using my G15 with CoD4, I set a couple macros up for in game messages, admin commands, and I set some of the default keys to them to make it a little bit easier for my gameplay style. It's not neccesary to use them, but experimenting with somedifferent keybinds or virtually keystrokes might help.
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