If you're serious about getting every last bit of performance and have the money, sure why not.
I went the cheaper route, sold my 2x16 and got 4x8, now I'm at 4133c17 1.4v ~39ns
Thats not really that good for 4133 also for 4 sticks you have to pump much more voltage into a 9900K/9900KS
im running 2 x 32GB Crucial Ballistix 3600 (BL2K32G36C16U4B) @ 15-17-17-34 560 CR1 1.35v for 39.3ns with a 9900KS Uncore 47
I was running 2 x 16GB Crucial Ballistix Sport LT 3200 @ 3500 16-18-18-36 560 CR1 1.35V Uncore 47 for about a year and it was 100% stable
I ordered 2 more
and even though i would pass memory tests i always had random crashes at 5ghz LLC Normal DVID -0.035mv with 4 sticks
if i pulled either set of 2 out it was 100% fine
if i Bumped DVID to +0.00 it was much better but still not 100%
if i dropped to CR2 it was much better but still not 100%
if i dropped the uncore to 43 it was much better but still not 100%
adding vccsa or vccio or memory voltage did nothing
If you are serious about the best latency and performance even on t topology boards you need to keep to 2 sticks
no matter what people tell you
I Had a Z390 M Gaming and just couldnt get it 100% stable with 4 sticks at my stable timings and voltage for 2 sticks
Replaced it for a Z390 Aorus Master as i put it down to the board and it was still the same
Crucial Ballistix 64GB 3600 Kit came into stock and thought f it and replaced my
4 x 16GB Duel Rank 3200 for 2 x 32GB Duel Rank 3600
and its been 100% fine ever since 4 sticks was a nightmare for stability with tight timings and low voltage
also going from 2 x 16GB Duel Rank to 4 x 16GB Duel rank or 2 x 32GB Duel Rank to 4 x 32GB Duel rank
looses you around 2ns at the exact same timings
now with 4 x Single rank i have no idea if its the same or not single rank may well be fine
but if i ever want to go 4 x 32GB 15-17-17-34 560 CR1 1.35v Duel rank i will have to bump my Vcore about 0.045mv
which im not willing to do as with a prime 95 avx small fft load that becomes uncoolable to keep below tj max
It will do 39.3 ns if i keep trying
Cores 1-5 52, Cores 6-7 51, Cores 8 50, Vcore Normal,DVID -0.035mv, LLC Normal