If you're playing Mafia 2, either of those cards would provide a benefit (the 260 slightly more so), but there's literally no other game aside from Mafia 2 that using either of those cards for physX is going make any sense.
Mafia 2 is a special case because of the way it's coded, wherein the cloth physX will run on the CPU no matter what unless you have a *dedicated* physX card. No other games work like this though, and the 580 SLI is plenty powerful enough to handle rendering + physX for anything else currently out there that supports hardware physX (which is a pathetically short list of games to begin with).