It should be like setting up 4 GPUs. Just be sure that you have 2 dummy plugs in each card, one for each GPU.
Originally Posted by Knitelife
If it will be just a folding rig, I suggest going xp, then you wont need dummy plugs. Just be sure to disable SLI and they will look like 4 regular GPUs.
EDIT: They are very difficult to set up. You would probably be better off just selling them to me instead