As long as the mainboard supports 3 PCIe at the minimum @x8/x8/x8, I don't see why not. The 460 is a perfect pair for 2x 5770s.
How to set it up, please have a look at my posts and what drivers/patch/PhysX SS to install. Just do the 3 simple steps. Do not over do it to complicate the unecessary.
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