Yes, it will work, though you could just use RivaTuner to make GTX 295 act like a Quadro when you're doing graphics and a GeForce when you're doing gaming. I think you would be able to make it think it was a FX 4800, but you'd have to check the options in RivaTuner.
Here's how:
http://www.techarp.com/showarticle.aspx?artno=539
Here's how:
http://www.techarp.com/showarticle.aspx?artno=539