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· Premium Member
23,047 Posts
Discussion Starter · #1 ·
Become a member of the Overclock.net [email protected] team. For more info on what [email protected] is and why it's a "good thing" visit here.

Let's Get Folding...

Download the folding program here.

Request a passkey here.
Team Number: 37726

For further information, post a thread in the Folding Forum.

Overclock.net team-specific stats here.

General stats page is here.

· Premium Member
2,012 Posts
Yeah, you all better get started to get a head start. Soon I'll switch all my folding power over from my old team to the overclock.net team. So you better get going!

Folding studies how proteins fold and mis fold. Many diseases are atributed to proteins mis-folding... Studying how they fold and stuff may help find a cure... so fold for the cure! I or someone else will put up a how to install and run folding. You can make it run in the background and there is a program you can use to monitor it. I will put together a self extracting .exe file that will have everything you need on it and already have the team number in, you would just have to enter in your name.

· Premium Member
2,012 Posts
I should also say this:

Folding At Home only uses the left over CPU processes. You can play a game w/ it running in the back ground or anything else no problem. I have my comp folding 24/7 except when I'm extreme benchmarking.

Folding runs your CPU at 99-100% usually. You can specify less... but why?

You download WU (work units) and it can take anywhere from a few hours to a few days to complete (depending on the work unit and your computer, w/ a very slow computer it can take several weeks). Different work units have different point values. Once finished, it sends the work unit to stanford and downloads another one. If you're not connected to the internet and don't have auto dial set, it won't be doing anything until it can download another one.

· Premium Member
10,636 Posts

I now have a reason to build up my AMD2000 and AMD3000 and possibly even my AMD 64 rigs. I didnt want to fold for just anyone, but I will gladly fold for Overclock.net!

Waiting on mobo from killacamaro, and maybe some money for cases and motherboards...then its on like donkey-kong!


· Registered
317 Posts
ARTICLE PROVIDED BY http://folding.stanford.edu/science.html

Proteins are necklaces of amino acids --- long chain molecules. Proteins are the basis of how biology gets things done. As enzymes, they are the driving force behind all of the biochemical reactions which make biology work. As structural elements, they are the main constituent of our bones, muscles, hair, skin and blood vessels. As antibodies, they recognize invading elements and allow the immune system to get rid of the unwanted invaders. For these reasons, scientists have sequenced the human genome -- the blueprint for all of the proteins in biology -- but how can we understand what these proteins do and how they work?


Since proteins play such fundamental roles in biology, scientists have sequenced the human genome. The genome is in a sense a "blueprint" for these proteins -- the genome contains the DNA code which specifies the sequence of the amino acids beads along the protein "necklace."


However, only knowing this sequence tells us little about what the protein does and how it does it. In order to carry out their function (eg as enzymes or antibodies), they must take on a particular shape, also known as a "fold." Thus, proteins are truly amazing machines: before they do their work, they assemble themselves! This self-assembly is called "folding."

One of our project goals is to simulate protein folding in order to understand how proteins fold so quickly and reliably, and to learn how to make synthetic polymers with these properties. Movies of the results of some of these simulation results can be found here.

PROTEIN FOLDING AND DISEASE: BSE (Mad Cow), Altzheimer's, ...

What happens if proteins don't fold correctly? Diseases such as Alzheimer's disease, cystic fibrosis, BSE (Mad Cow disease), an inherited form of emphysema, and even many cancers are believed to result from protein misfolding.

When proteins misfold, they can clump together ("aggregate"). These clumps can often gather in the brain, where they are believed to cause the symptoms of Mad Cow or Alzheimer's disease.

PROTEIN FOLDING AND NANOTECHNOLOGY: Building man made machines on the nanoscale

In addition to biomedical applications, learning about how proteins fold will also teach us how to design our own protein-sized "nanomachines" to do similar tasks. Of course, before nanomachines can carry out any activity, they must also be assembled.


It's amazing that not only do proteins self-assemble -- fold -- but they do so amazingly quickly: some as fast as a millionth of a second. While this time is very fast on a person's timescale, it's remarkably long for computers to simulate.

In fact, it takes about a day to simulate a nanosecond (1/1,000,000,000 of a second). Unfortunately, proteins fold on the tens of microsecond timescale (10,000 nanoseconds). Thus, it would take 10,000 CPU days to simulate folding -- i.e. it would take 30 CPU years! That's a long time to wait for one result!


To solve the protein folding problem, we need to break the microsecond barrier. Our group has developed a new way to simulate protein folding which can break the microsecond barrier by dividing the work between multiple processors in a new way -- with a near linear speed up in the number of processors. Thus, with 1000 processors, we can break the microsecond barrier and help unlock the mystery of how proteins fold.
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