-credit to Lutro0 and csm for the logo-
What is the Foldathon?
The Foldathon is a 2-day period each month where we Fold on any and all clients we can get our hands on. You might not be able to Fold 24/7, but if you're a Folder, there's no excuse not to Fold for these 48 hours.
This year, we're using every second Foldathon to highlight some of the lesser known diseases that the [email protected] Project researches (directly or indirectly). In the spot light this month is Parkinson's Disease.
How it works:Parkinson's disease (also known as Parkinson disease, Parkinson's, idiopathic parkinsonism, primary parkinsonism, PD, or paralysis agitans) is a degenerative disorder of the central nervous system. The motor symptoms of Parkinson's disease result from the death of dopamine-generating cells in the substantia *****, a region of the midbrain; the cause of this cell death is unknown. Early in the course of the disease, the most obvious symptoms are movement-related; these include shaking, rigidity, slowness of movement and difficulty with walking and gait. Later,cognitive and behavioural problems may arise, with dementia commonly occurring in the advanced stages of the disease. Other symptoms include sensory, sleep and emotional problems. PD is more common in the elderly, with most cases occurring after the age of 50.
The main motor symptoms are collectively called parkinsonism, or a "parkinsonian syndrome". Parkinson's disease is often defined as a parkinsonian syndrome that is idiopathic (having no known cause), although some atypical cases have a genetic origin. Many risk and protective factors have been investigated: the clearest evidence is for an increased risk of PD in people exposed to certain pesticides and a reduced risk in tobacco smokers. The pathology of the disease is characterized by the accumulation of a protein called alpha-synuclein into inclusions called Lewy bodies in neurons, and from insufficient formation and activity of dopamine produced in certain neurons within parts of the midbrain. Lewy bodies are the pathological hallmark of the idiopathic disorder, and the distribution of the Lewy bodies throughout the Parkinsonian brain varies from one individual to another. The anatomical distribution of the Lewy bodies is often directly related to the expression and degree of the clinical symptoms of each individual. Diagnosis of typical cases is mainly based on symptoms, with tests such as neuroimaging being used for confirmation.
Modern treatments are effective at managing the early motor symptoms of the disease, mainly through the use oflevodopa and dopamine agonists. As the disease progresses and dopaminergic neurons continue to be lost, a point eventually arrives at which these drugs become ineffective at treating the symptoms and at the same time produce a complication called dyskinesia, marked by involuntary writhing movements. Diet and some forms of rehabilitation have shown some effectiveness at alleviating symptoms. Surgery and deep brain stimulation have been used to reduce motor symptoms as a last resort in severe cases where drugs are ineffective. Research directions include investigations into new animal models of the disease and of the potential usefulness of gene therapy, stem cell transplants andneuroprotective agents. Medications to treat non-movement-related symptoms of PD, such as sleep disturbances and emotional problems, also exist.
The disease is named after the English doctor James Parkinson, who published the first detailed description in An Essay on the Shaking Palsy in 1817. Several major organizations promote research and improvement of quality of life of those with the disease and their families. Public awareness campaigns include Parkinson's disease day (on the birthday of James Parkinson, April 11) and the use of a red tulip as the symbol of the disease. People with parkinsonism who have enhanced the public's awareness include Michael J. Fox and Muhammad Ali.
Run [email protected] for Overclock.net (team number: 37726) during the specified times. Those who Fold will be entered into a drawing to win the prizes listed below. If you don't know what [email protected] is, feel free to make a thread in the forum or check these guides:
CPU and/or GPU Folding
Client for AMD GPUs only
Monday June 18th Noon EDT (GMT: 4pm) until June 20th Noon EDT.
• $25 PayPal - donated by admin - gboeds
• $25 PayPal - donated by admin - cchun39
• $25 PayPal - donated by admin - crystalhand
• Lifetime Overclocked account - donated by admin - royalflush5
• Lifetime Overclocked account - donated by admin - hatchet
• Lucid (Steam) - donated by aas88keyz - WonderMutt
Extra prizes this month:
So plenty of reason to get new people signed up this month; extra prize draw for you, and for them.As he did in January, admin has a few extra prizes for this Foldathon, using the same referral system, outlined below.
1) You refer someone to the Foldathon, and they name you as the referrer.
2) Any points they make for the Foldathon will then be the referrer's "Referred Points".
3) The three members with the most RPs will then win the following prizes:
1st place - OCN Ducky keyboard (switch of their choice) - BWG
2nd place - $50 through PayPal - rrims
3rd place - $25 through PayPal - Demented
Random OCN Ducky Keyboard - BiG-LiG
In addition, anyone who refers someone to the Foldathon (and they participate ) will then also be entered into a random draw for another OCN Ducky keyboard. The new users that were referred to the Foldathon will of course be entered into the main prize draw above.
You only need to sign up once.
If you'd like to be put on a reminder list for all future Foldathons, please join this group: Foldathon Participants
----> SIGN UP HERE <----
Courtesy of sks72, enter your name (during the Foldathon) into the following link to see your points total for the Foldathon so far:
Super duper script
:cheers: http://www.overclock.net/t/1270408/june-foldathon-parkinsons-disease-june-18th-start/0_50]June Foldathon (18th-20th) - Raising Awareness for Parkinson's Disease[/URL] :cheers: