Single powerful GPUs are still considered the better route unless you have an appetite for massive amounts of AA/AF and huge monitors that would make your 22" look like a toy. In general if a game doesn't have an SLI/CF profile in the driver you'll have to wait until the nvidia/ati release a profile for it (that's assuming they do).
You can try and force different multi GPU rendering methods on a game but you're unlikely to gain much. To finish off your motherboard does not support SLI and it's not recommended for CF either because of the way the lanes get split (16x/4x).
You can try and force different multi GPU rendering methods on a game but you're unlikely to gain much. To finish off your motherboard does not support SLI and it's not recommended for CF either because of the way the lanes get split (16x/4x).