Theres no problem with mounting it upside down had an old case that had an extra rack for hdds that once you mounted the hdds and inserted the cage had all 4 hdds facing straight up. Way its mounted doesnt matter just as long as its secure and not just swing from the molex
I have mine mounted on their edge on the bottom of my case with a 1" gap between them to keep them cool. I have a 120mm intake 1" in front of them and I have never seen them more than 2* above ambient.
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