Time to dremel into my cosmos 1000. Anyone have experience?

Use Aluminium oxide reinforced cutting disks.

Also, take your time, and tape off the general area of where you're going to be cutting.

Good luck!

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Although I wouldn't use a dremel, holesaw is preferred.

First advice: don't use a dremel to make the holes. I know, I know, I'm going to get a lot of response against this advice, but read for a second. You can go to any home improvement store and get a small hole-saw bit. This will create a nice circle for your holes. After that, use a dremel to "dremel-down" the burrs. Go to the screw area of the home improvement store and get rubber grommets to match the hole saw size. You won't snag any wires and it is extremely sleek.

EDIT: In my picture, look to the top right of the motherboard. That is an example of what I'm talking about. I have about 6 other holes like that hidden in my case.

I used a dremel with the reinforced bits, and cut away my fan guards and most of the top. You'll go through a lot of them