AFAIK the monitors can only be plugged into the main card to use eyefinity. This shouldn't be a problem as long as you have presumably 2 Active DVI to Display Port adapters and just use the other 2 as display port. Crossfire should run just fine, as long as you use the bridge, hope this helps.
OP you shouldn't need any adapters if your monitors have displayport. I believe those are only necessary when your monitor isn't equipped with displayport and you have to use DVI, like I did. I would just use DVI from the ASUS and 1 Dell, and use displayport on the other 2 Dells
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