that hi pitched squeal/whine is one or more of your capacitors (either on the motherboard or card itself). In my opinion, its simply annoying, and probably wont harm your system over time.
My last build (q6700, 780i mobo, 2x 8800GTs) had that squeal when the GPUs were oc'd, and i ran it like that for over a year, nothing bad happened.
My last build (q6700, 780i mobo, 2x 8800GTs) had that squeal when the GPUs were oc'd, and i ran it like that for over a year, nothing bad happened.