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Which components contribute the most to water cooling performance?

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Just wondering what you guys think, in a list of components from most to least important for a water cooling loop's performance. I currently understand the "priority" to be:


Care to discuss? I'll be putting together my first water cooling loop pretty soon, just want to know if there is anything else I should note before I finalize my configuration.

Also, what are some of the reasons that hold back the performance of AIO coolers? Even the ones with 240mm rads like the H100?