Most of the time, when you install a program you can choose where you want to install it, for example you go to install a program and the default is:
C:\Program Files (x86)\New Game\
let's assume your 2TB drive is labelled 'D:\', all you would need to do is change the 'C' to a 'D' so you end up with D:\Program Files (x86)\New Game
So whatever the drive letter of your 2TB drive is, just change it to that.