I have mine at auto, when I was going for 4GHZ I had to set really high vcore (1.4) and even then it wasn't too stable. I then set mine to 300ps and it seemed much more stable but the voltage and temps were still unbearable.
For "period stability" (the proper timing of electrical signals), it is standard practice, if say, you add 200 ps on the cpu, to add 100 ps on the IOH/Northbridge.
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