If you have positive case pressure, with a non reference cooler.
Here's my setup in my Fractal Design Arc Midi R2.
I have positive pressure front to back airflow going on.

I removed the PCI slot covers.

Back exhaust fan:

Top exhaust fan:

Top intake fan:

Temperatures where the PCI slot covers used to be (I measured the temperature of the DVI cable and one of the PCI horizontal pillars, not the actual GPU itself) - and they're hotter than the exhaust fans which means that instead of mixing fresh cool air with warmer GPU air and then exhausting it out the top and back, the GPU air is being pushed straight out the back of the case. Excellent


I can feel hot air blowing out of these open slots, which is a good thing.
Previously I ran Kombustor for 1 hour and got to a temperature of 80C while my intake temperature was 22.1C giving a delta of 57.9C for the GPU.
Then I ran Kombustor for 1 hour again but this time with the slot covers removed. Intake temperature of 24C and GPU temperature of 75C giving a delta of 51C.
That's a difference of 6.9C.
Since I have positive pressure I'm not going to worry about dust flying in, but I do hope that insects don't get in.
Just a little semi scientific test for you guys to try out on your own systems.
PS: I didn't think to record CPU temperatures (doh!), but I don't have another free 2 hours so I'll do it some time in the far future.
Here's my setup in my Fractal Design Arc Midi R2.
I have positive pressure front to back airflow going on.
I removed the PCI slot covers.
Back exhaust fan:
Top exhaust fan:
Top intake fan:
Temperatures where the PCI slot covers used to be (I measured the temperature of the DVI cable and one of the PCI horizontal pillars, not the actual GPU itself) - and they're hotter than the exhaust fans which means that instead of mixing fresh cool air with warmer GPU air and then exhausting it out the top and back, the GPU air is being pushed straight out the back of the case. Excellent

I can feel hot air blowing out of these open slots, which is a good thing.
Previously I ran Kombustor for 1 hour and got to a temperature of 80C while my intake temperature was 22.1C giving a delta of 57.9C for the GPU.
Then I ran Kombustor for 1 hour again but this time with the slot covers removed. Intake temperature of 24C and GPU temperature of 75C giving a delta of 51C.
That's a difference of 6.9C.
Since I have positive pressure I'm not going to worry about dust flying in, but I do hope that insects don't get in.
Just a little semi scientific test for you guys to try out on your own systems.
PS: I didn't think to record CPU temperatures (doh!), but I don't have another free 2 hours so I'll do it some time in the far future.