I think your PSU might be to blame. I had the same one and it kept turning off the pc under high load and power spikes with a 6900XT. Swapped to a corsair 850 and no problems so far. I'll recieve my 7900XTX later today. Will def report my findings here.
Thanks for your share

.
I've used power hog kit like TR1950X/2950X, RX Vega 64 with it no issues. It's Seasonic platform in Cooler Master branding, has no OCP, single 70A rail for 12V. So I'd be surprised if it's PSU, but open to idea.
** edit **
Back on UEFI 4303 Beta. I can't find GPU-Z v2.51.5 online,
@W1zzard.
SP4K initial run last night
SP4K this morning.
SP4K just now...
Wall plug watt meter show max ~470W AC side draw for total rig and screen (ASUS MG279Q), PSU can deliver 850W DC side. Jonnyguru site down, did ref that on purchase of V850, but TPU shows ~110% cross loading of PSU (see
table here) and I'm no way near that.
Looking at wall plug meter for last run, I don't think PSU is issue.
Leaning towards UEFI being issue.
i) Game Mode On/Off makes no difference on UEFI 4006/4201, insta black screen on GPU load on things that run on UEFI 4303 Beta.
ii) HW GPU scheduling On/Off makes no difference on UEFI 4006/4201, insta black screen on GPU load on things that run on UEFI 4303 Beta.
iii) SVM have on usually to allow VM, On/Off makes no difference on UEFI 4006/4201, insta black screen on GPU load on things that run on UEFI 4303 Beta.
iv) SAM On/Off makes no difference on UEFI 4006/4201, insta black screen on GPU load on things that run on UEFI 4303 Beta.
* edit 2 *
UEFI 4303 Beta
Ran SP4K 2 times back to back, wall meter total rig inc screen ~470W MAX, same POST of system 2x CB15 OpenGL bench ~225W MAX, same POST of system 2x RealBench benchmark ~475W MAX.
So far this is all I can run successfully...